Glutathione S-Transferase M1 (GSTM1) and Glutathione S-Transferase T1 (GSTT1) Null Polymorphisms, Smoking, and Their Interaction in Oral Cancer: A HuGE Review and Meta-Analysis
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منابع مشابه
Human Genome Epidemiology (HuGE) Review Glutathione S-TransferaseM1 (GSTM1) and Glutathione S-Transferase T1 (GSTT1) Null Polymorphisms, Smoking, and Their Interaction in Oral Cancer: A HuGE Review and Meta-Analysis
The association between glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms and oral cancer is not consistent across studies, and data on their interaction with smoking in oral cancer are lacking. The authors systematically searched PubMed and SciVerse Scopus for case-control studies examining the association between null genotypes of theGSTM1 andGST...
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The genes glutathione S-transferase M1 (GSTM1) (chromosome 1p13.3) and glutathione S-transferase T1 (GSTT1) (22q11.2) code for cytosolic enzymes glutathione S-transferase (GST)-mu and GST-theta, respectively, which are involved in phase 2 metabolism. Both genes may be deleted. There is geographic and ethnic variation in genotype frequencies for both genes. In developed countries, colorectal can...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2011
ISSN: 0002-9262,1476-6256
DOI: 10.1093/aje/kwq480